Advanced Search
ORIGINAL ARTICLE
Korean J Pediatr 2010 April;53(4) :548-553.
doi:https://doi.org/10.3345/kjp.2010.53.4.548
Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean population
Hwan Hee Jung (Jung HH), Won Ho Hahn (Hahn WH), Byoung Soo Cho (Cho BS), Sung Do Kim (Kim SD)
Department of Pediatrics, Kyunghee University College of Medicine, Seoul, Korea
Corresponding Author: Sung Do Kim ,Email: kimsungdo@empal.com
Copyright © 2010 by The Korean Pediatric Society
ABSTRACT
Purpose : IgA nephropathy (IgAN) is the most commonly occurring form of chronic glomerulonephritis in pediatric cases.Human leukocyte antigen (HLA) genes have been implicated in various inflammatory and autoimmune diseases. The present study was conducted to investigate the association between 2 single nucleotide polymorphisms (SNPs) of the HLA-G gene and childhood IgAN. Methods : The authors analyzed and compared HLA-G gene SNPs (rs1736936 and rs2735022) in 174 patients with childhood IgAN and in 438 healthy controls. In addition, IgAN patients were dichotomized and compared with respect to proteinuria (< and >4 mg/m2/hour), the presence or absence of podocyte foot process effacement, and the presence of pathologically early and advanced disease markers such as interstitial fibrosis, tubular atrophy, or global sclerosis. Results : No significant SNP frequency differences were observed for the HLA-G gene between IgAN patients and the control group. Moreover, no significantly associated SNP was observed with the presence of proteinuria, podocyte foot process effacement, or pathologically advanced markers. However, the haplotype, composed of rs1736936 and rs2735022, showed a significant association with the susceptibility to develop childhood IgAN (haplotype T/C: dominant model, P=0.049; haplotype C/T: recessive model, P =0.030). Conclusion : Our results indicate that rs1736936 and rs2735022 as the HLA-G gene promoter haplotype might be associated with the susceptibility to develop childhood IgAN in the Korean population.
Keywords: HLA-G | Polymorphism | IgA nephropathy | Childhood
TOOLS
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Supplementary Material  Supplementary Material
  E-Mail
Share:      
METRICS
744
View
3
Download
Register for e-submission
Register here to access the e-submission system of Korean J Pediatr for authors and reviewers.
Manuscript Submission
To submit a manuscript, please visit the Korean J Pediatr e-submission management system at http://submit.kjp.or.kr, read the Instructions for Authors, and log into the Korean J Pediatr e-submission system. For assistance with manuscript submission, please contact: kjpped@gmail.com.
Free archive
Anyone may access any past or current articles without logging in.
Korean Pediatric Society Office
#1606, Seocho World Officetel, 19 Seoun-ro, Seocho-gu, Seoul 137-070, Korea
TEL : +82-2-3473-7305    FAX : +82-2-3473-7307   E-mail: kjpped@gmail.com
BrowseCurrent IssueFor Authors and ReviewersAbout
Copyright© The Korean Pediatric Society. All right reserved.