Advanced Search
Korean J Pediatr 2010 April;53(4) :571-578.
Efficacy of levetiracetam in refractory childhood epilepsy
Keon Su Lee (Lee KS), Joon Won Kang (Kang JW)
Institute for Brain Research, Chungnam National University, Department of Pediatrics, College of Medicine, Chungnam National University, Daejeon, Korea
Corresponding Author: Keon Su Lee ,Email:
Copyright © 2010 by The Korean Pediatric Society
Purpose : To evaluate the efficacy and safety of levetiracetam adjunctive therapy for reducing the rate of seizure frequency in children with intractable pediatric epilepsy. Methods : We reviewed the medical records of 86 patients with intractable pediatric epilepsy who visited our hospital between March 1989 and February 2009. Levetiracetam was included in the previous anticonvulsant regimen for at least 6 months and the reduction in the rate of seizure frequency was determined in follow-up examinations. We analyzed demographic data, seizure types, antiepileptic drug history, levetiracetam dose, adverse effects of levetiracetam therapy, treatment outcome, electroencephalogram findings, etc. Results : More than 50% reduction in the seizure frequency was observed in 62 of the 86 (72.1%) patients; 44 patients (51.1%) became seizure free, while the seizure frequency increased in 5.8% patients. The associations between seizure reduction rate and age, associated diseases, seizure types, and seizure frequency before treatment were not significant. However, the duration of disease, dose of levetiracetam, duration and frequency of anticonvulsant administration before levetiracetam therapy were significantly correlated. Electroencephalogram findings and the cause of epilepsy showed partial correlation. Forty (46%) patients showed adverse symptoms; the symptoms in the order of their frequency were somnolence, hyperactivity, irritability, aggressiveness, tiredness, etc. Conclusion : The findings of our study provide the evidence that levetiracetam adjunctive therapy is efficacious and well tolerated in various refractory childhood epilepsy cases.
Keywords: Levetiracetam | Intractable epilepsy | Child
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Supplementary Material  Supplementary Material
Cognitive function of idiopathic childhood epilepsy  2012 May;55(5)
Efficacy of Antiepileptic Drug on the Benign Childhood Epilepsy with Centro-Temporal Spikes  2003 September;46(9)
Surgical Treatment for Intractable Childhood Epilepsy  1998 November;41(11)
Surgical Treatment in Childhood Intractable Epilepsy  1997 September;40(9)
The Effectf Zonisamide in Children with Refractory Epilepsies  1993 August;36(8)
Register for e-submission
Register here to access the e-submission system of Korean J Pediatr for authors and reviewers.
Manuscript Submission
To submit a manuscript, please visit the Korean J Pediatr e-submission management system at, read the Instructions for Authors, and log into the Korean J Pediatr e-submission system. For assistance with manuscript submission, please contact:
Free archive
Anyone may access any past or current articles without logging in.
Korean Pediatric Society Office
#1606, Seocho World Officetel, 19 Seoun-ro, Seocho-gu, Seoul 137-070, Korea
TEL : +82-2-3473-7305    FAX : +82-2-3473-7307   E-mail:
BrowseCurrent IssueFor Authors and ReviewersAbout
Copyright© The Korean Pediatric Society. All right reserved.