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Korean J Pediatr 2010 May;53(5) :648-652.
Brain abscess in Korean children: A 15-year single center study
Cha Gon Lee (Lee CG)1, Seong Hun Kang (Kang SH)1, Yae Jean Kim (Kim YJ)1, Hyung Jin Shin (Shin HJ)2, Hyun Shin Choi (Choi HS)1, Jee Hun Lee (Lee JH)1, Mun Hyang Lee (Lee MH)1
1Department of Pediatrics, School of Medicine, Sungkyunkwan University, Samsung Medical Center, Seoul, Korea
2Department of Neurosurgery, School of Medicine, Sungkyunkwan University, Samsung Medical Center, Seoul, Korea
Corresponding Author: Yae Jean Kim ,Email:
Copyright © 2010 by The Korean Pediatric Society
Purpose : A brain abscess is a serious disease of the central nerve system. We conducted this study to summarize the clinical manifestations and outcomes of brain abscesses. Methods : A retrospective chart review of pediatric patients diagnosed with brain abscesses from November 1994 to June 2009 was performed at Samsung Medical Center, Seoul, Korea. Results : Twenty-five patients were included in this study. On average, 1.67 cases per year were identified and the median age was 4.3 years. The common presenting clinical manifestations were fever (18/25, 72%), seizure (12/25, 48%), altered mental status (11/25, 44%), and signs of increased intracranial pressure (9/25, 36%). A total of 14 (56%) patients had underlying illnesses, with congenital heart disease (8/25, 32%) as the most common cause. Predisposing factors were identified in 15 patients (60%). The common predisposing factors were otogenic infection (3/25, 12%) and penetrating head trauma (3/25, 12%). Causative organisms were identified in 64% of patients (16/25). The causative agents were S. intermedius (n=3), S. aureus (n=3), S. pneumoniae (n=1), Group B streptococcus (n=2), E. coli (n=1), P. aeruginosa (n=1), and suspected fungal infection (n=5). Seven patients received medical treatment only while the other 18 patients also required surgical intervention. The overall fatality rate was 16% and 20% of patients had neurologic sequelae. There was no statistical association between outcomes and the factors studied. Conclusion : Although uncommon, a brain abscess is a serious disease. A high level of suspicion is very important for early diagnosis and to prevent serious consequences.
Keywords: Brain | Abscess | Child | Korea
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