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Korean J Pediatr 2010 August;53(8) :786-789.
Disease-specific pluripotent stem cells
Hoon-Chul Kang (Kang HC)
Department of Pediatrics, Pediatric Epilepsy Clinics, Severance Childrens Hospital, Epilepsy Research Institute, Yonsei University College of Medicine, Seoul, Korea
Corresponding Author: Hoon-Chul Kang ,Email:
Copyright © 2010 by The Korean Pediatric Society
Induced pluripotent stem (iPS) cells are generated by epigenetic reprogramming of somatic cells through the exogenous expression of transcription factors. Recently, the generation of iPS cells from patients with a variety of genetic diseases was found to likely have a major impact on regenerative medicine, because these cells self-renew indefinitely in culture while retaining the capacity to differentiate into any cell type in the body, thereby enabling disease investigation and drug development. This review focuses on the current state of iPS cell technology and discusses the potential applications of these cells for disease modeling; drug discovery; and eventually, cell replacement therapy.
Keywords: Induced pluripotent stem cells | Transcription factors
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