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ORIGINAL ARTICLE
Korean J Pediatr 2011 February;54(2) :79-85.
doi:https://doi.org/10.3345/kjp.2011.54.2.79
Antibiotic susceptibility and imaging findings of the causative microorganisms responsible for acute urinary tract infection in children: a five-year single center study
Ji Eun Yoon (Yoon JE)1, Wun Kon Kim (Kim WK)1, Jin Seok Lee (Lee JS)2, Kyeong-Seob Shin (Shin KS)1, Tae-Sun Ha (Ha TS)1
1Department of Pediatrics, Chungbuk National University College of Medicine, Cheongju, Korea
2Department of Laboratory Medicine, Chungbuk National University College of Medicine, Cheongju, Korea
Corresponding Author: Tae-Sun Ha ,Tel: +82.42-600-9090, Fax: +82.43-264-6620, Email: tsha@chungbuk.ac.kr
Copyright © 2011 by The Korean Pediatric Society
ABSTRACT
Purpose : We studied the differences in the antibiotic susceptibilities of the microorganisms that causeing urinary tract infections (UTI) in children to obtain useful information on appropriate drug selection for childhood UTI. Methods : We retrospectively analyzed the antibiotic susceptibilities of 429 microorganisms isolated from 900 patients diagnosed with UTI in the Department of Pediatrics, Chungbuk National University Hospital, from 2003 to 2008. Results : The most common causative microorganisms for UTI were Escherichia coli (81.4%), Klebsiella pneumoniae (8.4%), Enterobacter spp. (1.7%), and Proteus spp. (0.4%). E. coli showed relatively high susceptibility as compared to imipenem (100%), amikacin (97.7%), aztreonam (97.9%), cefepime (97.7%), and ceftriaxone (97.1%), while it showed relatively low susceptibility to gentamicin (GM) (79.0%), trimethoprim/sulfamethoxazole (TMP/SMX) (68.7%), ampicillin/sulbactam (33.0%), and ampicillin (AMP) (28.6%). There were no significant differences in the image findings for causative microorganisms. Conclusion : Gram-negative organisms showed high susceptibility to amikacin and third-generation cephalosporins, and low susceptibility to AMP, GM, and TMP/SMX. Therefore, the use of AMP or TMP/SMX as the first choice in empirical and prophylactic treatment of childhood UTI in Korea should be reconsidered and investigated further.
Keywords: Urinary tract infection | Escherichia coli | Antimicrobial susceptibility
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Microbiological spectrum and antibiotic susceptibility pattern in more than 24-month-old children with urinary tract infection: A6-year retrospective, single center experience  2009 October;52(10)
Antibiotic Sensitivity to the Major Causative Organisms of Acute Urinary Tract Infection in Children  2005 July;48(7)
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