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ORIGINAL ARTICLE
Korean J Pediatr 2011 March;54(3) :128-132.
doi:https://doi.org/10.3345/kjp.2011.54.3.128
Responses and adverse effects of carboplatin-based chemotherapy for pediatric intracranial germ cell tumors
Suntae Ji (Ji S)1, Hee Won Chueh (Chueh HW)1, Ju Youn Kim (Kim JY)2, Su Jin Lim (Lim SJ)2, Eun Joo Cho (Cho EJ)2, Soo Hyun Lee (Lee SH)1, Keon Hee Yoo (Yoo KH)1, Ki Woong Sung (Sung KW)1, Hong Hoe Koo (Koo HH)1
1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
2Childrens Cancer Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Corresponding Author: Hong Hoe Koo ,Tel: +82.2-3410-3524, Fax: +82.2-3410-0043, Email: hhkoo.koo@samsung.com
Copyright © 2011 by The Korean Pediatric Society
ABSTRACT
Purpose : Cisplatin-based chemotherapy has been commonly used for the treatment of intracranial germ cell tumors (IC-GCTs). However, this treatment exhibits some adverse effects such as renal problems and hearing difficulty. Carboplatin-based chemotherapy was administered to pediatric patients with IC-GCTs from August 2004 at the Samsung Medical Center. In this study, we assessed the responses and adverse effects of carboplatin-based chemotherapy in pediatric IC-GCTs patients according to the risk group, and compared the results with those of the previous cisplatin-based chemotherapy. Methods : We examined 35 patients (27 men and 8 women) diagnosed with IC-GCTs between August 2004 and April 2008 and received riskadapted carboplatin-based chemotherapy at the Samsung Medical Center. Patients were divided into either low-risk (LR) or high-risk (HR) groups and a retrospective analysis was performed using information from the medical records. Results : Although hematological complications were common, hearing difficulties or grade 3 or 4 creatinine level elevation were not observed in patients who underwent carboplatin-based chemotherapy. The frequency of febrile neutropenia did not differ between the risk groups. The overall survival was 100% and event-free survival (EFS) was 95.7 %. The EFS rate was 100% in the LR group and 90% in the HR group, respectively. Conclusion : Despite their common occurrence in high-risk patients, no lethal hematological complications were associated with carboplatinbased treatment. The current carboplatin-based chemotherapy protocol is safe and effective for the treatment of pediatric patients with IC-GCTs.
Keywords: Intracranial germ cell tumor | Carboplatin | Adverse effects
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Responses and Toxicities of Risk-adapted Chemotherapy in Pediatric Intracranial Germ Cell Tumors  2005 February;48(2)
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