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Korean J Pediatr 2011 April;54(4) :157-162.
Alteration of CD4+CD25+Foxp3+ T cell level in Kawasaki disease
Su Ye Sohn (Sohn SY), Young Wooh Song (Song YW), Yun Ku Yeo (Yeo YK), Yun Kyung Kim (Kim YK), Gi Young Jang (Jang GY), Chan Wook Woo (Woo CW), Jung Hwa Lee (Lee JH), Kwang Chul Lee (Lee KC)
Department of Pediatrics, Korea University College of Medicine, Seoul, Korea
Corresponding Author: Jung Hwa Lee ,Tel: +82.31-412-5090, Fax: +82.31-405-8591, Email:
Copyright © 2011 by The Korean Pediatric Society
Purpose : Exaggerated pro-inflammatory reactions during the acute phase of Kawasaki disease (KD) suggest the role of immune dysregulation in the pathogenesis of KD. We investigated the profiles of T regulatory cells and their correlation with the clinical course of KD. Methods : Peripheral blood mononuclear cells were collected from 17 KD patients during acute febrile and subacute afebrile phases. T cells expressing CD4, CD25, and Foxp3 were analyzed using flow cytometry, and the results were correlated with the clinical course of KD. Results : The percentage of circulating CD4+CD25highFoxp3+ T cells among CD4+ T cells was significantly higher during the subacute afebrile phase than during the acute febrile phase (1.10%1.22% vs. 0.55%0.53%, P=0.049). Although levels of CD4+CD25lowFoxp3+ T cells and CD4+CD25‒Foxp3+ T cells were only slightly altered, the percentage of CD4+CD25+Foxp3‒ T cells among CD4+ T cells was significantly lower during the subacute afebrile phase than during the acute febrile phase (2.96%1.95% vs. 5.64%5.69%, P=0.036). Consequently, the ratio of CD25highFoxp3+ T cells to CD25+Foxp3‒ T cells was higher during the subacute afebrile phase than during the acute febrile phase (0.45%0.57% vs. 0.13%0.13%, P=0.038). Conclusion : Decreased CD4+CD25highFoxp3+ T cells and/or an imbalanced ratio of CD4+CD25highFoxp3+ T cells to CD4+CD25+ Foxp3‒ T cells might play a role in KD development. Considering that all KD patients were treated with intravenous immunoglobulin (IVIG), recovery of CD4+CD25highFoxp3+ T cells during the subacute afebrile phase could be a mechanism of IVIG.
Keywords: Kawasaki disease | Regulatory T cell | CD25+ | Foxp3+
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