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Korean J Pediatr 2011 June;54(6) :246-252.
Outcomes of small for gestational age micropremies depending on how young or how small they are
Hee Joon Yu (Yu HJ), Eun Sun Kim (Kim ES), Jin Kyu Kim (Kim JK), Hye Soo Yoo (Yoo HS), So Yoon Ahn (Ahn SY), Yun Sil Chang (Chang YS), Won Soon Park (Park WS)
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Corresponding Author: Won Soon Park ,Tel: +82-2-3410-3523, Fax: +82-2-3410-0043, Email:
Copyright © 2011 by The Korean Pediatric Society
Purpose : The outcomes of small for gestational age (SGA) infants especially in extremely low birth weight infants (ELBWIs) are controversial. This study evaluated the mortality and morbidity of ELBWIs, focusing on whether or not they were also SGA. Methods : The medical records of 415 ELBWIs (birth weight <1,000 g), who were inborn and admitted to the Samsung Medical Center neonatal intensive care unit from January 2000 to December 2008, were reviewed retrospectively. Mortality and morbidities were compared by body size groups: very SGA (VSGA), birth weight 3rd percentile; SGA, 3rd to 10th percentile; and appropriate for gestational age (AGA) infants, >10th percentile for gestational age. For gestational subgroup analysis, groups were divided into infants with gestational age 24+6 weeks (subgroup I), 25+0 to 26+6 weeks (subgroup II), and 27+0 weeks (subgroup III). Results : Gestational age was 29+22+6 weeks in the VSGA infants (n=49), 27+52+2 weeks in the SGA infants (n=45), and 25+41+4 weeks in AGA infants (n=321). Birth weight was 692186.6 g, 768132.9 g, and 780142.5 g in the VSGA, SGA, and AGA groups, respectively. Cesarean section rate and maternal pregnancy-induced hypertension were more common in the VSGA and SGA than in AGA pregnancies. However, chorioamnionitis was more common in the AGA group. The mortalities of the lowest gestational group (subgroup I), and also of the lower gestational group (subgroup I+II) were significantly higher in the VSGA group than the SGA or AGA groups (P=0.020 and P=0.012, respectively). VSGA and SGA infants showed lower incidence in respiratory distress syndrome, ductal ligation, bronchopulmonary dysplasia, intraventricular hemorrhage than AGA group did. However, by multiple logistic regression analysis of each gestational subgroup, the differences were not significant. Conclusion : Of ELBWIs, extremely SGA in the lower gestational subgroups, had an impact on mortality, which may provide information useful for prenatal counseling.
Keywords: Small for gestational age | Extremely low birth weight infants | Mortality | Morbidity
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Consequences of being born small for gestational age : More than being small  2009 February;52(2)
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