| Usefulness of drug provocation tests in children with a history of adverse drug reaction |
| Hye Ran Na (Na HR), Jeong Min Lee (Lee JM), Jo Won Jung (Jung JW), Soo-Young Lee (Lee SY) |
| Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea |
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Corresponding Author:
Soo-Young Lee ,Tel: +82-31-219-5164, Fax: +82-31-219-5169, Email: jsjs87@ajou.ac.kr |
| Copyright © 2011 by The Korean Pediatric Society |
| ABSTRACT |
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Purpose : There are very few reports of adverse drug reactions (ADR)
and almost no study of drug provocation test (DPT) in Korean children.
We aimed to assess the role of DPT in children with unpredictable
ADRs, and compare the causative drugs and clinical characteristics
between detailed history of ADRs and result of DPTs.
Methods : We included 16 children who were experienced ADRs
referred to pediatric allergy clinic at Ajou University Hospital (January
2006 to December 2009). With various suspected drugs, 71 DPTs
were done in 16 patients using our own protocol, and skin tests to
antibiotics were combined in ADRs to antibiotics in medical history.
Results : There were 17 (23.9%) positive DPTs results out of 71
individual DPTs, and 11 patients (68.8%) from 16 patients were
positive to at least one drug. Drugs causing positive reactions were
acetaminophen in 5 (31%), Non-steroidal anti-inflammatory drugs
in 4 (25%), penicillin in 3 (19%), cephalosporin in 2 (13%), and cotrimoxazole,
macrolide and lactose in 1 each.
Conclusion : DPT seems a safe and useful procedure to confirm
causative drug and identify safely administering alternative drugs in
children with ADR. |
| Keywords:
Adverse drug reaction | Drug provocation test | Child
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