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Korean J Pediatr 2011 August;54(8) :340-344.
Log-transformed plasma level of brain natriuretic peptide during the acute phase of Kawasaki disease is quantitatively associated with myocardial dysfunction
Sunhee Bang (Bang S)1, Jeong Jin Yu (Yu JJ)1, Myung-Ki Han (Han MK)1, Hong Ki Ko (Ko HK)1, Sail Chun (Chun S)2, Hyung Soon Choi (Choi HS)3, Young-Hwue Kim (Kim YH)1, Jae-Kon Ko (Ko JK)1, In-Sook Park (Park IS)1
1Division of Pediatric Cardiology, Departments of Pediatrics University of Ulsan College of Medicine, Seoul, Korea
2Departments of Laboratory Medicine, University of Ulsan College of Medicine, Seoul, Korea
3Department of Pediatrics, Kosin University College of Medicine, Busan, Korea
Corresponding Author: Jeong Jin Yu ,Tel: +82-2-3010-3924, Fax: +82-2-473-3725, Email:
Copyright © 2011 by The Korean Pediatric Society
Purpose : Brain natriuretic peptide (BNP) has been considered a biochemical marker for myocarditis in Kawasaki disease. We performed this study to determine its quantitative significance. Methods : We attempted to correlate log-transformed BNP concentrations (log-BNP) and clinical, laboratory, and echocardiographic variables in 81 children with Kawasaki disease. Stepwise multiple linear regression analysis was used to determine the variables independently associated with log-BNP concentration. Results : Serum C-reactive protein level (P<0.0001), serum alanine aminotransferase concentration (P =0.0032), white blood cell count (P=0.0030), and left ventricular mass index (P=0.0024) were positively related with log-BNP, and hemoglobin level (P<0.0001), serum albumin level (P<0.0001), Na+ concentrations (P<0.0001), left ventricular fractional shortening (P=0.0080), and peak early diastolic tissue velocity of the left ventricular basal lateral segment (P=0.0045) were negatively related to the log-BNP concentration. Multiple regression analysis showed that serum albumin concentration (R2=0.31, P=0.0098) and left ventricular mass index (R2=0.09, P=0.0004) were significantly associated with the log-BNP concentration. Conclusion : Elevated BNP levels during the acute phase of Kawasaki disease may be attributable to cardiac dysfunction associated with the increase in left ventricular mass, and log-BNP concentration may be a quantitative biochemical marker of myocarditis in Kawasaki disease.
Keywords: Kawasaki disease | Myocarditis | Brain natriuretic peptide
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Age-adjusted plasma N-terminal pro-brain natriuretic peptide level in Kawasaki disease  2016 July;59(7)
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