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ORIGINAL ARTICLE
Korean J Pediatr 2011 September;54(9) :380-384.
doi:https://doi.org/10.3345/kjp.2011.54.9.380
Short term outcomes of topiramate monotherapy as a first-line treatment in newly diagnosed West syndrome
Gyu Min Lee (Lee GM), Kyung Suk Lee (Lee KS), Eun Hye Lee (Lee EH), Sajun Chung (Chung Sj)
Department of Pediatrics, Kyung Hee University School of Medicine, Seoul, Korea
Corresponding Author: Sajun Chung ,Tel: +82-2-958-8301, Fax: +82-2-958-8845, Email: sajchung@khmc.or.kr
Copyright © 2011 by The Korean Pediatric Society
ABSTRACT
Purpose : To investigate the efficacy of topiramate monotherapy in West syndrome prospectively. Methods : The study population included 28 patients (15 male and 13 female children aged 2 to 18 months) diagnosed with West syndrome. After a 2-week baseline period for documentation of the frequency of spasms, topiramate was initiated at 2 mg/kg/day. The dose was increased by 2 mg/kg every week to a maximum of 12 mg/ kg/day. Clinical assessment was based on the parents report and a neurological examination every 2 weeks for the first 2 months of treatment. The baseline electroencephalograms (EEGs) were compared with the post-treatment EEGs at 2 weeks and 1 month. Results : West syndrome was considered to be cryptogenic in 7 of the 28 patients and symptomatic in 21 patients. After treatment, 11 patients (39%) became spasm-free, 6 (21%) had more than 50% spasmsreduction, 3 (11%) showed less than 50% reduction, and 8 (29%) did not respond. The effective daily dose for achieving more than 50% reduction in spasm frequency, including becoming spasm-free, was found to be 5.81.1 mg/kg/day. Nine patients (32%) showed complete disappearance of spasms and hypsarrhythmia, and 11 (39%) showed improved EEG results. Despite adverse events (4 instances of irritability, 3 of drowsiness, and 1 of decreased feeding), no patients discontinued the medication. Conclusion : Topiramate monotherapy seems to be effective and well tolerated as a first line therapy for West syndrome and is not associated with serious adverse effects.
Keywords: West syndrome | Topiramate | Monotherapy
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