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Korean J Pediatr 2011 October;54(10) :422-424.
An adverse event following 2009 H1N1 influenza vaccination: a case of acute disseminated encephalomyelitis
Sang Teak Lee (Lee ST)1, Young June Choe (Choe YJ)1, Won Jin Moon (Moon WJ)2, Jin Woo Choi (Choi JW)2, Ran Lee (Lee R)3
1Division of National Immunization Program and Vaccine Preventable Disease, Korea Centers for Control
2Departments of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
3Departments of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
Corresponding Author: Ran Lee ,Tel: +82-2-2030-7557, Fax: +82-2-2030-7749, Email:
Copyright © 2011 by The Korean Pediatric Society
Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system that typically follows an infection or vaccination and has a favorable long-term prognosis. We describe the first reported case of ADEM after vaccination against novel influenza A (H1N1). A previously healthy 34-monthold boy who developed ADEM presented with a seizure and leftsided weakness 5 days after vaccination against novel influenza A (H1N1). Cerebrospinal fluid examination revealed elevated cell counts. T2-weighted images and fluid-attenuated inversion recovery images revealed multiple patchy hyperintense lesions in the frontal and parietal subcortical white matter and the left thalamus. After the administration of intravenous corticosteroid, the patients clinical symptoms improved and he recovered completely without neurologic sequelae.
Keywords: Acute disseminated encephalomyelitis | Novel influenza A (H1N1) | Vaccination | Child | Adverse drug event
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2 Cases of Acute Disseminated Encephalomyelitis  1993 April;36(4)
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