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ORIGINAL ARTICLE
Korean J Pediatr 2011 November;54(11) :456-462.
doi:https://doi.org/10.3345/kjp.2011.54.11.456
Effect of respiratory syncytial virus infection on regulated on activation, normal T-cells expressed and secreted production in a murine model of asthma
Yanghua Ju (Ju Y)1, Seung Jun Choi (Choi SJ)2, Huisu Lee (Lee Hs)2, Hyun Sook Kim (Kim HS)2, Sulmui Won (Won Sm)2, Yoon Hong Chun (Chun YH)2, Jong-Seo Yoon (Yoon JS)2, Hyun Hee Kim (Kim HH)2, Joon Sung Lee (Lee JS)2
1Department of Pediatrics, The First Hospital of Jilin University, Changchun, China
2Department of Pediatrics, The Catholic University of Korea School of Medicine, Seoul, Korea
Corresponding Author: Jong-Seo Yoon ,Tel: +82-2-2258-2828, Fax: +82-2-537-4544, Email: pedjsyoon@catholic.ac.kr
Copyright © 2011 by The Korean Pediatric Society
ABSTRACT
Purpose : Synthesis of regulated on activation, normal T-cells expressed and secreted (RANTES) in the airway has previously been shown to be elevated after respiratory syncytial virus (RSV) infection. However, since few studies have examined whether RSV-infected asthma patients express a higher level of RANTES than do normal individuals, we used a murine model of asthma to address this question. Methods : We prepared Dermatophagoides farinae -sensitized mice as an asthma model, and then infected them with RSV and analyzed the changes in airway responsiveness and the cell populations and cytokine levels of bronchoalveolar lavage fluid. Results : RANTES synthesis increased in response to RSV infection in both control mice and in asthma model (D. farinae) mice. However, there was no significant difference in the amount of RANTES produced following RSV infection between control and D. farinae mice. RSV infection affected neither interferon-synthesis nor airway responsiveness in either control or D. farinae mice. Conclusion : RSV infection did not induce more RANTES in a murine model of asthma than in control mice.
Keywords: Respiratory syncytial virus | RANTES | Animal models | Asthma
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