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ORIGINAL ARTICLE
Korean J Pediatr 2012 January;55(1) :11-17.
doi:https://doi.org/10.3345/kjp.2012.55.1.11
Comparison of the accuracy of neutrophil CD64 and C-reactive protein as a single test for the early detection of neonatal sepsis
Young Kwang Choo (Choo YK)1, Hyun-Seok Cho (Cho HS)1, In Bum Seo (Seo IB), hyeon-Soo Lee (Lee hS)
Departments of Clinical Diagnosis, Kangwon National University Hospital, Kangwon National University School of Medicine, Institute of Medical Sciences, Kangwon National University School of Medicine, Chuncheon, Korea
Departments of Pediatrics, Kangwon National University Hospital, Kangwon National University School of Medicine, Institute of Medical Sciences, Kangwon National University School of Medicine, Chuncheon, Korea
1Departments of Pediatrics, Kangwon National University Hospital, Kangwon National University School of Medicine, Korea
Corresponding Author: hyeon-Soo Lee ,Tel: +82-33-258-2318, Fax: +82-33-258-2418, Email: premee@kangwon.ac.kr
Copyright © 2012 by The Korean Pediatric Society
ABSTRACT
Purpose : Early identification of neonatal sepsis is a global issue because of limitations in diagnostic procedures. The objective of this study was to compare the diagnostic accuracy of neutrophil CD64 and C-reactive protein (CRP) as a single test for the early detection of neonatal sepsis. Methods : A prospective study enrolled newborns with documented sepsis (n=11), clinical sepsis (n=12) and control newborns (n=14). CRP, neutrophil CD64, complete blood counts and blood culture were taken at the time of the suspected sepsis for the documented or clinical group and at the time of venipuncture for laboratory tests in control newborns. Neutrophil CD64 was analyzed by flow cytometry. Results : CD64 was significantly elevated in the groups with documented or clinical sepsis, whereas CRP was not significantly increased compared with controls. For documented sepsis, CD64 and CRP had a sensitivity of 91% and 9%, a specificity of 83% and 83%, a positive predictive value of 83% and 33% and a negative predictive value of 91% and 50%, respectively, with a cutoff value of 3.0 mg/dL for CD64 and 1.0 mg/dL for CRP. The area under the receiver-operating characteristic curves for CD64 index and CRP were 0.955 and 0.527 (P<0.01), respectively. Conclusion : These preliminary data show that diagnostic accuracy of CD64 is superior to CRP when measured at the time of suspected sepsis, which implies that CD64 is a more reliable marker for the early identification of neonatal sepsis as a single determination compared with CRP.
Keywords: Neutrophil CD64 | C-reactive protein | Neonatal sepsis
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