Advanced Search
Korean J Pediatr 2012 March;55(3) :111-113.
A case of Hashimoto`s encephalopathy presenting with seizures and psychosis
Min-Joo Lee (Lee MJ), Hae-Sang Lee (Lee HS), Jin-Soon Hwang (Hwang JS), Da-Eun Jung (Jung DE)
Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea
Corresponding Author: Da-Eun Jung ,Tel: +82-31-219-4445, Fax: +82-31-219-5169, Email:
Copyright © 2012 by The Korean Pediatric Society
Hashimotos encephalopathy (HE) is a rare, poorly understood, autoimmune disease characterized by symptoms of acute or subacute encephalopathy associated with increased anti-thyroid antibody levels. Here, we report a case of a 14-year-old girl with HE and briefly review the literature. The patient presented with acute mental changes and seizures, but no evidence of infectious encephalitis. In the acute stage, the seizures did not respond to conventional antiepileptic drugs, including valproic acid, phenytoin, and topiramate. The clinical course was complicated by the development of acute psychosis, including bipolar mood, insomnia, agitation, and hallucinations. The diagnosis of HE was supported by positive results for antithyroperoxidase and antithyroglobulin antibodies. Treatment with methylprednisolone was effective; her psychosis improved and the number of seizures decreased. HE is a serious but curable, condition, which might be underdiagnosed if not suspected. Anti-thyroid antibodies must be measured for the diagnosis. HE should be considered in patients with diverse neuropsychiatric manifestations.
Keywords: Hashimoto`s encephalopathy | Seizures | Psychosis
PDF Links  PDF Links
Full text via DOI  Full text via DOI
  via Pubmed
Full text via PMC  Full text via PMC
via Pubreader  via PubReader
Download Citation  Download Citation
Supplementary Material  Supplementary Material
A case of acute necrotizing encephalopathy associated with parainfluenza virus infection  2012 April;55(4)
A case of megalencephalic leukoencephalopathy with subcortical cysts  2008 December;51(12)
A case of simultaneously identified glycogen storage disease and mucopolysaccharidosis  2008 June;51(6)
A case of lethal kwashiorkor caused by feeding only with cereal grain  2008 March;51(3)
A Case of Encephalopathy Presented with Motor Aphasia and Quadriplegia Following Intrathecal Methotrexate  2001 September;44(9)
Register for e-submission
Register here to access the e-submission system of Korean J Pediatr for authors and reviewers.
Manuscript Submission
To submit a manuscript, please visit the Korean J Pediatr e-submission management system at, read the Instructions for Authors, and log into the Korean J Pediatr e-submission system. For assistance with manuscript submission, please contact:
Free archive
Anyone may access any past or current articles without logging in.
Korean Pediatric Society Office
#1606, Seocho World Officetel, 19 Seoun-ro, Seocho-gu, Seoul 137-070, Korea
TEL : +82-2-3473-7305    FAX : +82-2-3473-7307   E-mail:
BrowseCurrent IssueFor Authors and ReviewersAbout
Copyright© The Korean Pediatric Society. All right reserved.