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Korean J Pediatr 2017 August;60(8) :248-253.
Published online 2017 August 15.        doi:
Effects of cord blood vitamin D levels on the risk of neonatal sepsis in premature infants
Birgul Say, Nurdan Uras, Suzan Sahin, Halil Degirmencioglu, Serife Suna Oguz, Fuat Emre Canpolat
Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey
Corresponding Author: Birgul Say ,Tel: +90-312-3065270, Fax: +90-312-3114645, Email:
Copyright © 2017 by The Korean Pediatric Society
Purpose: Vitamin D plays a key role in immune function. Vitamin D deficiency may play a role in the pathogenesis of infections, and low levels of circulating vitamin D are strongly associated with infectious diseases. In this study, we aimed to evaluate the effects of low vitamin D levels in cord blood on neonatal sepsis in preterm infants.
Methods: One hundred seventeen premature infants with gestational age of <37 weeks were enrolled. In the present study, severe vitamin D deficiency (group 1) was defined as a 25-hydroxyvitamin D (25(OH)D) concentration <5 ng/mL; vitamin D insufficiency (group 2), 25(OH)D concentration 5 ng/mL and <15 ng/mL; and vitamin D sufficiency (group 3), 25(OH)D concentration 15 ng/mL.
Results: Sixty-three percent of the infants had deficient levels of cord blood vitamin D (group 1), 24% had insufficient levels (group 2), and 13% were found to have sufficient levels (group 3). The rate of neonatal sepsis was higher in group 2 than in groups 1 and 3.
Conclusion: There was no significant relationship between the cord blood vitamin D levels and the risk of neonatal sepsis in premature infants.
Keywords: Early onset sepsis | Cord vitamin D level | Late onset sepsis | Preterm infants
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