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Korean J Pediatr 2012 August;55(8) :286-292.
Published online 2012 August 15.        doi:
Continuous renal replacement therapy in neonates weighing less than 3 kg
Young Bae Sohn (Sohn YB)1, Kyung Hoon Paik (Paik KH)1, Hee Yeon Cho (Cho HY)1, Su Jin Kim (Kim SJ)2, Sung Won Park (Park SW)1, Eun Sun Kim (Kim ES)1, Yun Sil Chang (Chang YS)1, Won-Soon Park (Park WS)1, Yoon-Ho Choi (Choi YH)3, Dong-Kyu Jin (Jin DK)1
1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
2Department of Pediatrics, Myongji Hospital, Kwandong University College of Medicine, Goyang, Korea
3Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Corresponding Author: Dong-Kyu Jin ,Tel: +82-2-3410-3539, Fax: +82-2-3410-0043, Email:
Copyright © 2012 by The Korean Pediatric Society
Purpose: Continuous renal replacement therapy (CRRT) is becoming the treatment of choice for supporting critically ill pediatric patients. However, a few studies present have reported CRRT use and outcome in neonates weighing less than 3 kg. The aim of this study is to describe the clinical application, outcome, and complications of CRRT in small neonates. Methods: A retrospective review was performed in 8 neonatal patients who underwent at least 24 hours of pumped venovenous CRRT at the Samsung Medical Center in Seoul, Korea, between March 2007 and July 2010. Data, including demographic characteristics, diagnosis, vital signs, medications, laboratory, and CRRT parameters were recorded. Results: The data of 8 patients were analyzed. At the initiation of CRRT, the median age was 5 days (corrected age, 38+2 weeks to 23 days), and the median body weight was 2.73 kg (range, 2.60 to 2.98 kg). Sixty-two patient-days of therapy were reviewed; the median time for CRRT in each patient was 7.8 days (range, 1 to 37 days). Adverse events included electrolyte disturbances, catheter-related complications, and CRRTrelated hypotension. The mean circuit functional survival was 13.98.6 hours. Overall, 4 patients (50%) survived; the other 4 patients, who developed multiorgan dysfunction syndrome, died. Conclusion: The complications of CRRT in newborns are relatively high. However, the results of this study suggest that venovenous CRRT is feasible and effective in neonates weighing less than 3 kg under elaborate supportive care. Furthermore, for using potential benefit of CRRT in neonates, efforts are required for prolonging filter survival.
Keywords: Critical illness | Infant | Renal replacement therapy | Treatment outcome
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Supplementary Material  Supplementary Material
Acute treatment of hyperammonemia by continuous renal replacement therapy in a newborn patient with ornithine transcarbamylase deficiency  2011 October;54(10)
Outcome of Continuous Renal Replacement Therapy in Children  2005 January;48(1)
Continuous Renal Replacement Therapy in Pediatrics  2004 January;47(1)
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