Advanced Search
CASE REPORT
Korean J Pediatr 2012 August;55(8) :293-296.
Published online 2012 August 15.        doi:https://doi.org/10.3345/kjp.2012.55.8.293
A case of cytomegalovirus-negative Ménétriers disease with eosinophilia in a child
Keun Hyung Son (Son KH)1, Jeong Ja Kwak (Kwak JJ)2, Jae Ock Park (Park JO)1
1Departments of Pediatrics University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea
2Departments of Pathology University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea
Corresponding Author: Jae Ock Park ,Tel: +82-32-621-5403, Fax: +82-32-621-5662, Email: jop50@schmc.ac.kr
Copyright © 2012 by The Korean Pediatric Society
ABSTRACT
Ménétriers disease is a rare form of acquired gastropathy characterized by giant rugal folds in the stomach and protein-losing gastropathy. Children with Ménétriers disease tend to follow a benign self-limited course with symptoms typically completely resolving within 2 to 10 weeks in contrast to the chronic course in adults. A 9-year-old girl presented with a history of gradually worsening abdominal distension, increasing body weight, and abdominal pain for 2 weeks. Physical examination on admission indicated periorbital swelling, pitting edema in both the legs, and abdominal distension with mild diffuse tenderness and shifting dullness. Laboratory tests on admission showed hypoalbuminemia, hypoproteinemia, and peripheral eosinophilia. The test result for anticytomegalovirus immunoglobulin M was negative. Increased fecal alpha 1 anti-trypsin excretion was observed. Radiological findings showed massive ascites and pleural effusion in both the lungs. On gastroscopy, large gastric folds, erythema, erosion, and exudation were noted in the body and fundus of the stomach. Microscopic findings showed infiltration of eosinophils and neutrophils in the gastric mucosa. Her symptoms improved with conservative treatment from day 7 of hospitalization and resolved completely.
Keywords: Ménétriers disease | Gastritis hypertrophic | Hypoalbuminemia | Protein-losing enteropathies | Eosinophilia | Cytomegalovirus
 
REFERENCE
1. Chouraqui JP, Roy CC, Brochu P, Gregoire H, Morin CL, Weber AM. Menetrier's disease in children: report of a patient and review of sixteen other cases. Gastroenterology 1981;80(5 pt 1):1042–1047.
2. Occena RO, Taylor SF, Robinson CC, Sokol RJ. Association of cytomegalovirus with Menetrier's disease in childhood: report of two new cases with a review of literature. J Pediatr Gastroenterol Nutr 1993;17:217–224.
3. Wolfsen HC, Carpenter HA, Talley NJ. Menetrier's disease: a form of hypertrophic gastropathy or gastritis?. Gastroenterology 1993;104:1310–1319.
4. Scharschmidt BF. The natural history of hypertrophic gastrophy (Menetrier's disease). Report of a case with 16 year follow-up and review of 120 cases from the literature. Am J Med 1977;63:644–652.
5. Lim YJ, Rhee PL, Kim YH, Lee SJ, Lee MS, Kang TW, et al. Clinical features of Menetrier's disease in Korea. Korean J Gastrointest Endosc 2000;21:909–916.
6. Hoffer V, Finkelstein Y, Balter J, Feinmesser M, Garty BZ. Ganciclovir treatment in Menrtrier's disease. Acta Paediatr 2003;92:983–985.
7. Cho JR, Kang SK, Kim YH, Choe YH. A case of Menetrier's disease associated with cytomegalovirus infection. J Korean Pediatr Soc 2001;44:1197–1200.
8. Kawasaki M, Hizawa K, Aoyagi K, Nakamura S, Fujishima M. Menetrier's disease associated with Helicobacter pylori infection: resolution of enlarged gastric folds and hypoproteinemia after antibacterial treatment. Am J Gastroenterol 1997;92:1909–1912.
9. Yamada M, Sumazaki R, Adachi H, Ahmed T, Matsubara T, Hori T, et al. Resolution of protein-losing hypertrophic gastropathy by eradication of Helicobacter pylori. Eur J Pediatr 1997;156:182–185.
10. Jun DW, Kim DH, Kim SH, Song MH, Lee HH, Kim SH, et al. Menetrier's disease associated with herpes infection: response to treatment with acyclovir. Gastrointest Endosc 2007;65:1092–1095.
11. Ben Amitai D, Zahavi I, Dinari G, Garty BZ. Transient protein-losing hypertrophic gastropathy associated with Mycoplasma pneumoniae infection in childhood. J Pediatr Gastroenterol Nutr 1992;14:237–239.
12. Choi WJ, Lee BY, Lee HJ, Oh HK, Hwang JB. Cytomegalovirus-induced childhood menetrier's disease with peripheral eosinophilia. Korean J Pediatr Gastroenterol Nutr 2004;7:87–91.
13. Tokuhara D, Okano Y, Asou K, Tamamori A, Yamano T. Cytomegalovirus and Helicobacter pylori co-infection in a child with Ménétrier disease. Eur J Pediatr 2007;166:63–65.
14. Fieber SS. Hypertrophic gastritis; report of two cases and analysis of fifty pathologically verified cases from the literature. Gastroenterology 1955;28:39–69.
15. Schroder JS. Protein-losing gastroenteropathy: case report of Menetrier's disease and suggested etiology. South Med J 1961;54:249–252.
16. Barnard JA, Beauchamp RD, Russell WE, Dubois RN, Coffey RJ. Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Gastroenterology 1995;108:564–580.
17. Toubia N, Schubert ML. Menetrier's disease. Curr Treat Options Gastroenterol 2008;11:103–108.
18. Morinville V, Bernard C, Forget S. Foveolar hyperplasia secondary to cow's milk protein hypersensitivity presenting with clinical features of pyloric stenosis. J Pediatr Surg 2004;39:E29–E31.
19. Coffey RJ, Washington MK, Corless CL, Heinrich MC. Menetrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach. J Clin Invest 2007;117:70–80.
20. Takaya J, Kawamura Y, Kino M, Kawashima Y, Yamamoto A, Kobayashi Y. Menetrier's disease evaluated serially by abdominal ultrasonography. Pediatr Radiol 1997;27:178–180.
21. Sandberg DH. Hypertrophic gastropathy (Menetrier's disease) in childhood. J Pediatr 1971;78:866–868.
22. Baker A, Volberg F, Sumner T, Moran R. Childhood Menetrier's disease: four new cases and discussion of the literature. Gastrointest Radiol 1986;11:131–134.
23. Cogliatti SB, Schmid U, Schumacher U, Eckert F, Hansmann ML, Hedderich J, et al. Primary B-cell gastric lymphoma: a clinicopathological study of 145 patients. Gastroenterology 1991;101:1159–1170.
24. Edelman MJ, March TL. Eosinophilic gastroenteritis. Am J Roentgenol Radium Ther Nucl Med 1964;91:773–778.
25. Siaw EK, Sayed K, Jackson RJ. Eosinophilic gastroenteritis presenting as acute gastric perforation. J Pediatr Gastroenterol Nutr 2006;43:691–694.
26. Talley NJ, Shorter RG, Phillips SF, Zinsmeister AR. Eosinophilic gastroenteritis: a clinicopathological study of patients with disease of the mucosa, muscle layer, and subserosal tissues. Gut 1990;31:54–58.
27. Nelson RS, Lanza FL. The endoscopic diagnosis of gastric lymphoma. Gross characteristics and histology. Gastrointest Endosc 1974;21:66–68.
28. Oderda G, Cinti S, Cangiotti AM, Forni M, Ansaldi N. Increased tight junction width in two children with Menetrier's disease. J Pediatr Gastroenterol Nutr 1990;11:123–127.
29. Kraut JR, Powell R, Hruby MA, Lloyd-Still JD. Menetrier's disease in childhood: report of two cases and a review of the literature. J Pediatr Surg 1981;16:707–711.
30. Burdick JS, Chung E, Tanner G, Sun M, Paciga JE, Cheng JQ, et al. Treatment of Menetrier's disease with a monoclonal antibody against the epidermal growth factor receptor. N Engl J Med 2000;343:1697–1701.
31. Rothenberg M, Pai R, Stuart K. Successful use of octreotide to treat Menetrier's disease: a rare cause of abdominal pain, weight loss, edema, and hypoalbuminemia. Dig Dis Sci 2009;54:1403–1407.
TOOLS
PDF Links  PDF Links
Full text via DOI  Full text via DOI
  via Pubmed
Full text via PMC  Full text via PMC
via Pubreader  via PubReader
Download Citation  Download Citation
Supplementary Material  Supplementary Material
  E-Mail
Share:      
METRICS
1,733
View
4
Download
A case of regression of atypical dense deposit disease without C3 deposition in a child  2010 July;53(7)
Register for e-submission
Register here to access the e-submission system of Korean J Pediatr for authors and reviewers.
Manuscript Submission
To submit a manuscript, please visit the Korean J Pediatr e-submission management system at http://submit.kjp.or.kr, read the Instructions for Authors, and log into the Korean J Pediatr e-submission system. For assistance with manuscript submission, please contact: kjpped@gmail.com.
Free archive
Anyone may access any past or current articles without logging in.
Korean Pediatric Society Office
#1606, Seocho World Officetel, 19 Seoun-ro, Seocho-gu, Seoul 137-070, Korea
TEL : +82-2-3473-7305    FAX : +82-2-3473-7307   E-mail: kjpped@gmail.com
BrowseCurrent IssueFor Authors and ReviewersAbout
Copyright© The Korean Pediatric Society. All right reserved.