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ORIGINAL ARTICLE
Korean J Pediatr 2012 September;55(9) :344-349.
Published online 2012 September 14.        doi:https://doi.org/10.3345/kjp.2012.55.9.344
Urinary 6-sulfatoxymelatonin level in girls and its relationship with obesity
Jieun Lee (Lee JE)1, Juyoung Yoon (Yoon JY)1, Jin A Lee (Lee JA)2, Seong Yong Lee (Lee SY)2, Choong Ho Shin (Shin CH)1, Sei Won Yang (Yang SW)1
1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
2Department of Pediatrics, SMG-SNU Boramae Medical Center, Seoul, Korea
Corresponding Author: Seong Yong Lee ,Tel: +82-2-870-2363, Fax: +82-2-870-3866, Email: gnoygnoes@hanmail.net
Copyright © 2012 by The Korean Pediatric Society
ABSTRACT
Purpose: Short sleep duration is associated with obesity. Urinary 6-sulfatoxymelatonin (6-OHMS), the principal metabolite of melatonin, is closely related with sleep. We evaluated the difference in urinary 6-OHMS levels between obese girls and normal weight girls, and the relationship of urinary 6-OHMS with other hormones regulating body weight and metabolism. Methods: A total of 79 girls (6.3 to 12.4 years) were included in this study, of whom 34 were obese; 15, overweight; and 30, normal-weight. We examined their pubertal status and bone age. Fasting serum levels of total ghrelin, leptin, insulin, and first morning urinary 6-OHMS were measured. Homeostatic model assessment-insulin resistance (HOMAIR) was calculated from the fasting insulin and glucose levels. Results: There was no significant difference in the creatinine adjusted 6-OHMS levels between the obese girls and the control group. Urinary 6-OHMS did not show any correlations with body mass index (BMI), BMI percentile, total ghrelin, leptin, and HOMA-IR. Negative correlations were found between urinary 6-OHMS levels and chronological and bone ages. Conclusion: Our results suggest that melatonin production is not reduced consistently in obese girls.
Keywords: Obesity | Melatonin | 6-Sulfatoxymelatonin | Child
 
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