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Korean J Pediatr 2012 September;55(9) :354-357.
Published online 2012 September 14.        doi:
Neuro-Behçet disease presented diplopia with hemiparesis following minor head trauma
Ja Yun Choi (Choi JY)1, Sun Young Park (Park SY)1, In Ok Hwang (Hwang IO)2, Young Hwan Lee (Lee YH)1
1Department of Pediatrics, Yeungnam University College of Medicine, Daegu, Korea
2Department of Pediatrics, CHA Gumi Medical Center, Gumi, Korea
Corresponding Author: Young Hwan Lee ,Tel: +82-53-620-4381, Fax: +82-53-629-2252, Email:
Copyright © 2012 by The Korean Pediatric Society
Behçet disease (BD) is rare in childhood. We report a 9-year-old boy with neuro-Behçet disease who presented diplopia and weakness on the left side after a cerebral concussion. Brain magnetic resonance imaging (MRI) revealed hyperintensity of the right mesodiencephalic junction on T2-weighted and fluid attenuated inversion recovery images. Prednisolone administration resulted in complete remission and normalization of abnormal MRI finding. Brain MRI is a useful diagnostic tool when the neurological sign is the first symptom of subclinical BD.
Keywords: Neuro-Behçet disease | Cerebral concussion | Child
1. Inaba G, Vinken PJ. Behcet's disease. In: Vinken PJ, Bruyn GW, Klawans HL, Toole JFVascular diseases. Part II. Amsterdam: Elsevier; 198. pp. 593-610. Inaba G, Vinken PJ. Behcet's disease. In: Vinken PJ, Bruyn GW, Klawans HL, Toole JFVascular diseases. Part II. Amsterdam: Elsevier; 198. pp. 593-610. (Handbook of clinical neurology series; vol. 56)
2. Serdaroglu P. Behcet's disease and the nervous system. J Neurol 1998;245:197–205.
3. International Study Group for Behcet's Disease. Criteria for diagnosis of Behcet's disease. Lancet 1990;335:1078–1080.
4. James MA. Use of the Medical Research Council muscle strength grading system in the upper extremity. J Hand Surg Am 2007;32:154–156.
5. Kone-Paut I, Bernard JL. Behcet disease in children. Arch Fr Pediatr 1993;50:145–154.
6. Weiner SM, Otte A, Schumacher M, Juengling FD, Brink I, Nitzsche EU, et al. Neuro-Behçet's syndrome in a patient not fulfilling criteria for Behçet's disease: clinical features and value of brain imaging. Clin Rheumatol 2000;19:231–234.
7. Kocer N, Islak C, Siva A, Saip S, Akman C, Kantarci O, et al. CNS involvement in neuro-Behçet syndrome: an MR study. AJNR Am J Neuroradiol 1999;20:1015–1024.
8. Miller DH, Ormerod IE, Gibson A, du Boulay EP, Rudge P, McDonald WI. MR brain scanning in patients with vasculitis: differentiation from multiple sclerosis. Neuroradiology 1987;29:226–231.
9. Iizuka T, Sakai F. Neurosarcoidosis. Nihon Rinsho 2002;60:1785–1793.
10. Fujikawa S, Suemitsu T. Behcet disease in children: a nationwide retrospective survey in Japan. Acta Paediatr Jpn 1997;39:285–289.
11. Jones TB, Basso DM, Sodhi A, Pan JZ, Hart RP, MacCallum RC, et al. Pathological CNS autoimmune disease triggered by traumatic spinal cord injury: implications for autoimmune vaccine therapy. J Neurosci 2002;22:2690–2700.
12. Hirohata S, Suda H, Hashimoto T. Low-dose weekly methotrexate for progressive neuropsychiatric manifestations in Behcet's disease. J Neurol Sci 1998;159:181–185.
13. Kone-Paut I, Yurdakul S, Bahabri SA, Shafae N, Ozen S, Ozdogan H, et al. Clinical features of Behcet's disease in children: an international collaborative study of 86 cases. J Pediatr 1998;132:721–725.
14. Hentati F, Fredi M, Gharbi N, Ben Hamida M. Clinical and biological aspects of neuro-Behcet's (NB) in Tunisia. In: Wechsler B, Godeau PBehcet's disease. Proceedings of the Sixth International Conference on Behcet's disease; 1993 Jun 30-Jul 1; Paris, France. Amsterdam: Elsevier Saunders; 1993. pp. 415-418.
15. Akman-Demir G, Serdaroglu P, Tasci B. The Neuro-Behçet Study Group. Clinical patterns of neurological involvement in Behcet's disease: evaluation of 200 patients. Brain 1999;122(Pt 11):2171–2182.
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