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Korean J Pediatr 2012 November;55(11) :414-419.
Published online 2012 September 15.        doi:
Early neurodevelopment in very low birth weight infants with mild intraventricular hemorrhage or those without intraventricular hemorrhage
Il Rak Choi (Choi IP)1, Jang Hoon Lee (Lee JH)1, Moon Sung Park (Park MS)1, Ji Yeon Kim (Kim JY)2, Kyu Hee Park (Park KH)2, Gun-Ha Kim (Kim GH)2, So-Hee Eun (Eun SH)2
1Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea
2Department of Pediatrics, Korea University College of Medicine, Seoul, Korea
Corresponding Author: So-Hee Eun ,Tel: +82-31-412-5096, Fax: +82-31-405-8591, Email:
Copyright © 2012 by The Korean Pediatric Society
Purpose: This study aimed to assess early development in very low birth weight (VLBW) infants with mild intraventricular hemorrhage (IVH) or those without IVH and to identify the perinatal morbidities affecting early neurodevelopmental outcome. Methods: Bayley Scales of Infant Development-II was used for assessing neurological development in 49 infants with a birth weight <1,500 g and with low grade IVH (grade II) or those without IVH at a corrected age of 12 months. Results: Among the 49 infants, 19 infants (38.8%) showed normal development and 14 (28.6%) showed abnormal mental and psychomotor development. Infants with abnormal mental development (n=14) were mostly male and had a longer hospitalization, a higher prevalence of patent ductus arteriosus (PDA) and bronchopulmonary dysplasia (BPD), and were under more frequent postnatal systemic steroid treatment compared with infants with normal mental development (n=35, P<0.05). Infants with abnormal psychomotor development (n=29) had a longer hospitalization and more associated PDA compared to infants with normal psychomotor development (n=20, P<0.05). Infants with abnormal mental and psychomotor development were mostly male and had a longer hospitalization and a higher prevalence of PDA and BPD compared to infants with normal mental and psychomotor development (n=19, P<0.05). Using multiple logistic regression analysis, a longer duration of hospitalization and male gender were found to be significant risk factors. Conclusion: Approximately 62% of VLBW infants with low grade IVH or those without IVH had impaired early development.
Keywords: nfant premature | Intracranial hemorrhages | Growth & development
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Neurodevelopmental outcomes of very low birth weight infants and extremely low birth weight infants in Korea, 1984-2008  2009 January;52(1)
Changes of neurodevelopmental outcomes and risk factors of very low birth weight infants below 1,500 g, in the last 10 years  2006 October;49(10)
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