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Korean J Pediatr 2013 February;56(2) :45-51.
Published online 2012 October 05.        doi:
Noninvasive diagnosis of pediatric nonalcoholic fatty liver disease
Hye Ran Yang (Yang HR)
Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
Corresponding Author: Hye Ran Yang ,Tel: +82-31-787-7285, Fax: +82-31-787-4054, Email:
Copyright © 2013 by The Korean Pediatric Society
Because nonalcoholic steatohepatitis can progress towards cirrhosis even in children, early detection of hepatic fibrosis and accurate diagnosis of nonalcoholic fatty liver disease (NAFLD) are important. Although liver biopsy is regarded as the gold standard of diagnosis, its clinical application is somewhat limited in children due to its invasiveness. Noninvasive diagnostic methods, including imaging studies, biomarkers of inflammation, oxidative stress, hepatic apoptosis, hepatic fibrosis, and noninvasive hepatic fibrosis scores have recently been developed for diagnosing the spectrum of NAFLD, particularly the severity of hepatic fibrosis. Although data and validation are still lacking for these noninvasive modalities in the pediatric population, these methods may be applicable for pediatric NAFLD. Therefore, noninvasive imaging studies, biomarkers, and hepatic fibrosis scoring systems may be useful in the detection of hepatic steatosis and the prediction of hepatic fibrosis, even in children with NAFLD.
Keywords: Nonalcoholic fatty liver disease | Fibrosis | Diagnosis | Obesity | Child
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