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Korean J Pediatr 2012 December;55(12) :462-469.
Published online 2012 October 15.        doi:
Effect of early postnatal neutropenia in very low birth weight infants born to mothers with pregnancyinduced hypertension
Yang Hee Park (Park YH), Gyung Min Lee (Lee GM), Jung Min Yoon (Yoon JM), Enn Jung Cheon (Cheon EJ), Kyung Ok Ko (Ko KO), Yung Hyuk Lee (Lee YH), Jae Woo Lim (Lim JW)
Department of Pediatrics, Konyang University College of Medicine, Daejeon, Korea
Corresponding Author: Jae Woo Lim ,Tel: +82-42-600-9230, Fax: +82-42-600-9090, Email:
Copyright © 2012 by The Korean Pediatric Society
Purpose: In this study, we aimed to investigate the perinatal clinical conditions of very low birth weight (VLBW) infants born to mothers with pregnancy-induced hypertension (PIH) focusing on the effects of early postnatal neutropenia. Methods: We reviewed the medical records of 191 VLBW infants who were born at Konyang University Hospital, between March 2003 and May 2011. We retrospectively analyzed the clinical characteristics of the infants and their mothers and compared the incidence of perinatal diseases and mortality of the infants according to the presence or absence of maternal PIH and neutropenia on the first postnatal day. Results: Infants born to mothers with PIH showed an increased incidence of neutropenia on the first postnatal day (47.4%), cesarean delivery, and intrauterine growth restriction. When the infants born to mothers with PIH showed neutropenia on the first postnatal day, their incidence of respiratory distress syndrome (RDS) was increased (P=0.031); however, the difference was not found to be significant through logistic regression analysis. In all the VLBW infants, neutropenia on the first postnatal day was correlated with the development of RDS. The incidence of the other perinatal diseases involving sepsis and mortality did not significantly differ according to the presence or absence of neutropenia in infants born to mothers with PIH. Conclusion: In VLBW infants born to mothers with PIH, the incidence of neutropenia on the first postnatal day was increased and it was not significantly correlated with the development of perinatal diseases involving RDS, sepsis, and mortality.
Keywords: Pregnancy-induced hypertension | Neutropenia | Very low birth weight | Preterm infants | Perinatal diseases
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Supplementary Material  Supplementary Material
Early neurodevelopment in very low birth weight infants with mild intraventricular hemorrhage or those without intraventricular hemorrhage  2012 November;55(11)
Effect of severe neonatal morbidities on long term outcome in extremely low birthweight infants  2010 June;53(6)
Gastrointestinal surgery in very low birth weight infants : Clinical characteristics  2009 March;52(3)
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