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REVIEW ARTICLE
Korean J Pediatr 2012 October;55(10) :367-370.
Published online 2012 July 25.        doi:https://doi.org/10.3345/kjp.2012.55.10.367
Renal scar formation after urinary tract infection in children
Young Seo Park (Park YS)
Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Corresponding Author: Young Seo Park ,Tel: +82-2-3010-3376, Fax: +82-2-473-3725, Email: yspark@amc.seoul.kr
Copyright © 2012 by The Korean Pediatric Society
ABSTRACT
Urinary tract infection (UTI) is a common bacterial illness in children. Acute pyelonephritis in children may lead to renal scarring with the risk of later hypertension, preeclampsia during pregnancy, proteinuria, and renal insufficiency. Until now, vesicoureteral reflux (VUR) has been considered the most important risk factor for post-UTI renal scar formation in children. VUR predisposes children with UTI to pyelonephritis, and both are associated with renal scarring. However, reflux nephropathy is not always acquired; rather, it reflects refluxassociated congenital dysplastic kidneys. The viewpoint that chronic kidney disease results from renal maldevelopment-associated VUR has led to questioning the utility of any regimen directed at identifying or treating VUR. Despite the recognition that underlying renal anomalies may be the cause of renal scarring that was previously attributed to infection, the prevention of renal scarring remains the goal of all therapies for childhood UTI. Therefore, children at high risk of renal scar formation after UTI should be treated and investigated until a large clinical study and basic research give us more information.
Keywords: Urinary tract infection | Renal scar | Vesico-ureteral reflux | Child
 
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