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ORIGINAL ARTICLE
Korean J Pediatr 2012 December;55(12) :470-473.
Published online 2012 October 22.        doi:https://doi.org/10.3345/kjp.2012.55.12.470
Detection Rate and Clinical Impact of Respiratory Viruses in Children with Kawasaki Disease
Ja Hye Kim (Kim JH)1, Jeong Jin Yu (Yu JJ)1, Jina Lee (Lee JN)1, Mi-Na Kim (Kim NM)2, Hong Ki Ko (Ko HK)1, Hyung Soon Choi (Choi HS)3, Young-Hwue Kim (Kim YH)1, Jae-Kon Ko (Ko JK)1
1Department of Pediatrics, College of Medicine, University of Ulsan, Seoul, Korea
2Department of Laboratory Medicine, College of Medicine, University of Ulsan, Seoul, Korea
3Department of Pediatrics, Kosin University Gospel Hospital, Busan, Korea
Corresponding Author: Jeong Jin Yu ,Tel: +82-2-3010-3924, Fax: +82-2-473-3725, Email: pediatrist@medimail.co.kr
Copyright © 2012 by The Korean Pediatric Society
ABSTRACT
Purpose: The purpose of this prospective case-control study was to survey the detection rate of respiratory viruses in children with Kawasaki disease (KD) by using multiplex reverse transcriptasepolymerase chain reaction (RT-PCR), and to investigate the clinical implications of the prevalence of respiratory viruses during the acute phase of KD. Methods: RT-PCR assays were carried out to screen for the presence of respiratory syncytial virus A and B, adenovirus, rhinovirus, parainfluenza viruses 1 to 4, influenza virus A and B, metapneumovirus, bocavirus, coronavirus OC43/229E and NL63, and enterovirus in nasopharyngeal secretions of 55 KD patients and 78 control subjects. Results: Virus detection rates in KD patients and control subjects were 32.7% and 30.8%, respectively (P=0.811). However, there was no significant association between the presence of any of the 15 viruses and the incidence of KD. Comparisons between the 18 patients with positive RT-PCR results and the other 37 KD patients revealed no significant differences in terms of clinical findings (including the prevalence of incomplete presentation of the disease) and coronary artery diameter. Conclusion: A positive RT-PCR for currently epidemic respiratory viruses should not be used as an evidence against the diagnosis of KD. These viruses were not associated with the incomplete presentation of KD and coronary artery dilatation.
Keywords: Coronary aneurysm | Mucocutaneous lymph node syndrome | Respiratory tract infections | Viruses | Reverse transcriptase polymerase chain reaction
 
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