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ORIGINAL ARTICLE
Korean J Pediatr 2013 February;56(2) :80-85.
Published online 2012 October 25.        doi:https://doi.org/10.3345/kjp.2013.56.2.80
Selenium and leptin levels in febrile seizure: a case-control study in children
Abolfazl Khoshdel1, Neda Parvin2, Maedeh Abbasi3
1Departments of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran
2Departments of Nursing, Shahrekord University of Medical Sciences, Shahrekord, Iran
3Departments of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
Corresponding Author: Neda Parvin ,Tel: +98-381-333-5648, Fax: +98-381-333-5648, Email: np285@yahoo.com
Copyright © 2013 by The Korean Pediatric Society
ABSTRACT
Purpose: Febrile seizures (FS) are seizures that occur between the age of 6 and 60 months, but its pathophysiology still is not fully understood. There is limited information about the correlation between levels of selenium and leptin with FS. This study aimed to determine the relationship between serum levels of selenium and leptin in children with FS.
Methods: This case-control study was conducted in a University Hospital in Shahrekord, Iran, in 2011. The serum levels of selenium and leptin of 25 children with simple febrile seizure (case group) were compared with 25 febrile children without seizure (control group) in acute phase and after three months. The levels of serum selenium and leptin were measured by flame atomic absorption spectrophotometer and enzyme-linked immunosorbent assay method, respectively.
Results: In acute phase, the mean serum level of selenium in case and control groups were 95.88 42.55 and 113.2554.43 g/dL, respectively, and difference was not significant (P =0.415), but after three months, this level had a significant increase in both groups (P<0.001). In acute phase, the mean serum leptin level in case and control groups were 0.940.5 and 0.980.84 ng/mL, respectively, but difference was not significant (P =0.405). After three months, serum leptin level had no significant change in both groups (P =0.882).
Conclusion: These observations suggest that serum levels of selenium and leptin have not specific relation with FS but overllay is lower, however, further study is recommended. Also selenium level in stress and acute phase was significantly lower than recovery phase.
Keywords: Febrile seizures | Leptin | Selenium
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