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Korean J Pediatr 2013 January;56(1) :37-41.
Published online 2013 January 15.        doi:
Idiopathic acute eosinophilic pneumonia in a 14-month-old girl
Ha Neul Park (Park HN)1, Bo Hyun Chung (Chung BY)1, Jung Eun Pyun (Pyun JE)1, Kwang Chul Lee (Lee KC)1, Ji Tae Choung (Choung JT)1, Choon Hak Lim (Lim CH)2, Young Yoo (Yoo Y)1
1Departments of Pediatrics, Korea University Anam Hospital, Seoul, Korea
2Departments of Anaesthesiology and Pain Medicine, Korea University Anam Hospital, Seoul, Korea
Corresponding Author: Young Yoo ,Tel: +82-2-920-5090, Fax: +82-2-922-7476, Email:
Copyright © 2013 by The Korean Pediatric Society
Idiopathic acute eosinophilic pneumonia (IAEP), characterized by acute febrile respiratory failure associated with diffuse radiographic infiltrates and pulmonary eosinophilia, is rarely reported in children. Diagnosis is based on an association of characteristic features including acute respiratory failure with fever, bilateral infiltrates on the chest X-ray, severe hypoxemia and bronchoalveolar lavage fluid >25% eosinophils or a predominant eosinophilic infiltrate in lung biopsies in the absence of any identifiable etiology. We present a 14-month-old girl who was admitted to our pediatric intensive care unit because of acute respiratory distress. She had a fever, dry cough, and progressive dyspnea for 1 day. Chest X-ray showed multifocal consolidations, increased interstitial markings, parenchymal emphysema and pneumothorax. IAEP was confirmed by marked pulmonary infiltrates of eosinophils in the lung biopsy specimen. Most known causes of acute eosinophilic pneumonia, such as exposure to causative drugs, toxins, second-hand smoking and infections were excluded. Her symptoms were resolved quickly after corticosteroid therapy.
Keywords: Pulmonary eosiophilia | Idiopathic | Respiratory distress | Child
1. Allen J. Acute eosinophilic pneumonia. Semin Respir Crit Care Med 2006;27:142–147.
2. Cottin V, Cordier JF. Eosinophilic pneumonias. Allergy 2005;60:841–857.
3. Sauvaget E, Dellamonica J, Arlaud K, Sanfiorenzo C, Bernardin G, Padovani B, et al. Idiopathic acute eosinophilic pneumonia requiring ECMO in a teenager smoking tobacco and cannabis. Pediatr Pulmonol 2010;45:1246–1249.
4. Philit F, Etienne-Mastroianni B, Parrot A, Guerin C, Robert D, Cordier JF. Idiopathic acute eosinophilic pneumonia: a study of 22 patients. Am J Respir Crit Care Med 2002;166:1235–1239.
5. Oermann CM, Panesar KS, Langston C, Larsen GL, Menendez AA, Schofield DE, et al. Pulmonary infiltrates with eosinophilia syndromes in children. J Pediatr 2000;136:351–358.
6. Pope-Harman AL, Davis WB, Allen ED, Christoforidis AJ, Allen JN. Acute eosinophilic pneumonia: a summary of 15 cases and review of the literature. Medicine (Baltimore) 1996;75:334–342.
7. Allen JN, Davis WB. Eosinophilic lung diseases. Am J Respir Crit Care Med 1994;150(5 Pt 1):1423–1438.
8. Jeon EJ, Kim KH, Min KH. Acute eosinophilic pneumonia associated with 2009 influenza A (H1N1). Thorax 2010;65:268–270.
9. Brieu N, Guyon G, Rodiere M, Segondy M, Foulongne V. Human bocavirus infection in children with respiratory tract disease. Pediatr Infect Dis J 2008;27:969–973.
10. Kantola K, Hedman L, Arthur J, Alibeto A, Delwart E, Jartti T, et al. Seroepidemiology of human bocaviruses 1-4. J Infect Dis 2011;204:1403–1412.
11. Schildgen O. Human bocavirus: increasing evidence for virulence. Pediatr Pulmonol 2010;45:118–119.
12. Edner N, Castillo-Rodas P, Falk L, Hedman K, Soderlund-Venermo M, Allander T. Life-threatening respiratory tract disease with human bocavirus-1 infection in a 4-year-old child. J Clin Microbiol 2012;50:531–532.
13. Ursic T, Steyer A, Kopriva S, Kalan G, Krivec U, Petrovec M. Human bocavirus as the cause of a life-threatening infection. J Clin Microbiol 2011;49:1179–1181.
14. Daimon T, Johkoh T, Sumikawa H, Honda O, Fujimoto K, Koga T, et al. Acute eosinophilic pneumonia: thin-section CT findings in 29 patients. Eur J Radiol 2008;65:462–467.
15. Liu KT, Wu MH, Chiu CH, Tung SM, Wu YJ, Chang SC. Idiopathic acute eosinophilic pneumonia. J Chin Med Assoc 2006;69:330–333.
16. Mochimaru H, Kawamoto M, Fukuda Y, Kudoh S. Clinicopathological differences between acute and chronic eosinophilic pneumonia. Respirology 2005;10:76–85.
17. Vahid B, Marik PE. An 18-year-old woman with fever, diffuse pulmonary opacities, and rapid onset of respiratory failure: idiopathic acute eosinophilic pneumonia. Chest 2006;130:1938–1941.
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